Quantitative Profiling of Oxylipins in Acute Experimental Intracerebral Hemorrhage

Quantitative Intracerebral Hemorrhage Localization.

BACKGROUND AND PURPOSE The location of intracerebral hemorrhage (ICH) is currently described in a qualitative way; we provide a quantitative framework for estimating ICH engagement and its relevance to stroke outcomes. METHODS We analyzed 111 patients with ICH from the Minimally Invasive Surgery Plus Recombinant-Tissue Plasminogen Activator for Intracerebral Evacuation (MISTIE) II clinical tr...

Quantitative intracerebral brain hemorrhage analysis

In this paper a system for 3-D quantitative analysis of human spontaneous intracerebral brain hemorrhage (ICH) is described. The purpose of the developed system is to perform quantitative 3-D measurements of the parameters of ICH region and from computed tomography (CT) images. The measured parameter in this phase of the system development is volume of the hemorrhage region. The goal of the pro...

Acute Statin Treatment Improves Recovery after Experimental Intracerebral Hemorrhage.

BACKGROUND AND PURPOSE We have previously demonstrated that 2-week treatment of experimental intracerebral hemorrhage (ICH) with a daily dose of 2 mg/kg statin starting 24 hours post-injury exerts a neuroprotective effect. The present study extends our previous investigation and tests the effect of acute high-dose (within 24 hours) statin therapy on experimental ICH. MATERIAL AND METHODS Fift...

SRC kinase inhibition improves acute outcomes after experimental intracerebral hemorrhage.

BACKGROUND AND PURPOSE The mechanisms by which intracerebral hemorrhages produce changes of blood flow and metabolism, cell death, and behavioral abnormalities are complex. In this study, we begin to test the hypothesis that intracerebral hemorrhage activates Src kinases that phosphorylate other molecules to produce cell injury and behavioral deficits after intracerebral hemorrhage (ICH). MET...

[Somatosensory evoked potential in experimental intracerebral hemorrhage].